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Tell your doctor if you have or have ever had TB, if you have lived in a country where TB is common, or if you have been around someone who has TB. If necessary, your doctor will give you medicine to treat this infection before you begin using etanercept injection.

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Your doctor will perform a skin test to see if you have an inactive TB infection and may order blood tests to see if you have an inactive hepatitis B infection. In this case, etanercept injection may increase the risk that your infection will become more serious and you will develop symptoms. You may be infected with tuberculosis (TB, a type of lung infection) or hepatitis B (a type of liver disease) but do not have any symptoms of the disease. If you have any of the following symptoms before you begin your treatment or if you experience any of the following symptoms during or shortly after your treatment, call your doctor immediately: weakness sweating difficulty breathing sore throat cough coughing up bloody mucus fever weight loss extreme tiredness diarrhea stomach pain flu-like symptoms warm, red, or painful skin or other signs of infection. Your doctor will monitor you for signs of infection during and shortly after your treatment.

Also tell your doctor if you are taking medications that decrease the activity of the immune system such as the following: abatacept (Orencia) anakinra (Kineret) azathioprine (Imuran) steroids including dexamethasone, methylprednisolone (Medrol), prednisolone (Prelone) and prednisone or methotrexate (Rheumatrex). Ask your doctor if you do not know if these infections are common in your area. You should also tell your doctor if you live or have ever lived in areas such as the Ohio and Mississippi river valleys where severe fungal infections are more common. Also tell your doctor if you have or have ever had diabetes, human immunodeficiency virus (HIV), acquired immunodeficiency syndrome (AIDS), or any other condition that affects your immune system. This includes minor infections (such as open cuts or sores), infections that come and go (such as cold sores) and chronic infections that do not go away. Tell your doctor if you often get any type of infection or if you think you may have any type of infection now.

These infections may need to be treated in a hospital and may cause death. Using etanercept injection may decrease your ability to fight infection and increase the risk that you will get a serious infection, including severe viral, bacterial, or fungal infections that spread throughout the body.